Hormone replacement therapy: a 2008 perspective

Graphic summary of the main increased and decreased morbidities per annum reported in the Women’s Health Initiative (WHI) for the combined HRT a and oestrogen-only arms b compared with placebo per 10,000 women years in women aged 50 to 79 at trial entry (mean age 63). Data for women under the age of 60 years in the WHI have now been published for many outcomes in a variety of publications and have been combined for both regimens in c and d. WHI was not powered for such sub-analyses and significance levels are not shown.