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Research Article| Volume 9, ISSUE 2, P106-110, June 1999

Prophylactic antibiotics in gynaecology

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      Abstract

      Antimicrobial prophylaxis in gynaecological surgery remained controversial for more than 30 years until properly designed, controlled studies revealed their value in defined situations. Although controversy may still exist concerning the benefits of one antibiotic versus another, the concept of using perioperative antibiotics to prevent postoperative infections should become commonplace in gynaecological surgery and the outcome should be audited. Surgical-site infection surveillance and risk-factor analysis will reveal opportunities for improvement.
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      References

        • Haley R.W.
        • Culver D.H.
        • White J.W.
        • et al.
        The nationwide nosocomial rate: a new need for vital statistics.
        Am J Epidemiol. 1985; 121: 159-167
        • Emmerson A.M.
        • Enstone J.E.
        • Griffin M.
        • et al.
        The second national prevalence survey of infection in hospitals - overview of the results.
        J Hosp Infect. 1996; 32: 175-190
        • Burke J.F.
        The effective period of preventive antibiotic action in experimental incisions and dermal lesions.
        Surgery. 1961; 50: 161-168
        • Polk H.C.
        • Lopez-Major J.F.
        Postoperative wound infection: a prospective study of determinant factors and prevention.
        Surgery. 1969; 66: 97-103
        • Bergamini T.M.
        • Polk H.C.
        The importance of tissue antibiotic activity in the prevention of operative wound infection.
        J Antimicrob Chemother. 1989; 23: 301-313
        • Emmerson A.M.
        A microbiologist's view of factors contributing to infection.
        New Horizons (Soc Crit Care Med). 1998; 6: S3-S10
        • Lee J.T.
        Wound infection surveillance.
        Infect Dis Clin North Am. 1992; 6: 643-656
        • MacKenzie I.Z.
        Reducing hospital stay after abdominal hysterectomy.
        Br J Obstet Gynaecol. 1996; 103: 175-178
        • Taylor G.
        • Herrick T.
        • Mah M.
        Wound infections after hysterectomy: opportunities for practice improvement.
        Am J Infect Control. 1998; 26: 254-257
        • Gjønnaess H.
        Antimicrobial prophylaxis in gynaecological and obstetric surgery.
        Scand. J Infect Dis. 1990; : 52-67
        • Hemsell D.
        • Heard M.
        • Nobles B.
        • et al.
        Single-dose prophylaxis for vaginal and abdominal hysterectomy.
        Am J Obstet Gynecol. 1987; 157: 498-501
        • Houang E.
        • Ahmet Z.
        Intraoperative wound contamination during abdominal hysterectomy.
        J Hosp Infect. 1991; 19: 181-189
        • Soper D.
        • Bump R.C.
        • Hurt W.G.
        Wound infection after abdominal hysterectomy: effect of the depth of subcutaneous tissue.
        Am J Obstet Gynecol. 1995; 173: 465-471
        • National Academy of Sciences - National Research Council
        Post-operative wound infections: the influences of ultraviolet irradiation on the operating room and various other factors.
        Ann Surg. 1964; 160: 1-132
        • Horan T.C.
        • Gaynes R.P.
        • Martone W.J.
        • et al.
        CDC definition of nósocomial surgical site infections 1992: a modification of CDC definitions of surgical wound infections.
        Am J Infect Control. 1992; 20: 271-274
        • Culver D.H.
        • Horan T.C.
        • Gaynes R.P.
        • et al.
        Surgical wound infection rates by wound class, operative procedure and patient risk index. National Nosocomial Infections Surveillance System.
        Am J Med. 1991; 91: 152S-157S
        • Polk B.F.
        Antimicrobial prophylaxis to prevent mixed bacterial infection.
        J Antimicrob Chemother. 1981; 8: 115-129
        • Mittendorf R.
        • Aronson M.P.
        • Berry R.E.
        • et al.
        Avoiding serious infections associated with abdominal hysterectomy: a metaanalysis of antibiotic prophylaxis.
        Am J Obstet Gynecol. 1993; 169: 1119-1120
        • Guglielmo B.J.
        • Hohn D.C.
        • Koo P.J.
        • et al.
        Antibiotic prophylaxis in surgical procedures.
        Arch Surg. 1983; 118: 943-955
        • Davey P.G.
        • Duncan I.D.
        • Edward D.
        • et al.
        Cost-benefit analysis of cephradine and mezlocillin prophylaxis for abdominal and vaginal hysterectomy.
        Br J Obstet Gynaecol. 1988; 95: 1170-1178
        • Larsson P.
        • Platz-Christensen J.
        • Thejls H.
        • et al.
        Incidence of pelvic inflammatory disease after first-trimester legal abortion in women with bacterial vaginosis after treatment with metronidazole: a double-blind randomised study.
        Am J Obstet Gynecol. 1992; 166: 100-103
        • Sawaya G.F.
        • Grady D.
        • Kierlikowske K.
        • et al.
        Antibiotics at the time of induced abortion: the case for universal prophylaxis based on a meta-analysis.
        Obstet Gynecol. 1996; 87: 884-890
        • Blackwell A.L.
        • Thomas P.D.
        • Wareham K.
        • et al.
        Health gains from screening for infection of the lower genital tract in women attending for termination of pregnancy.
        Lancet. 1993; 342: 206-210
        • Penny G.C.
        • Thomson M.
        • Norman J.
        • et al.
        A randomised comparison of strategies for reducing infections complications of induced abortion (Aberdeen).
        Br J Obstet Gynaecol. 1998; 105: 599-604
      1. D T B. 1998; 36: 13-15
        • Sinei S.
        • Schulz K.
        • Lamptey P.
        • et al.
        Preventing IUCD-related pelvic infection: the efficacy of prophylactic doxycycline at insertion.
        Br J Obstet Gynaecol. 1990; 97: 412-419
        • Walsh T.
        • Grimes D.
        • Frezieres R.
        • et al.
        Randomised controlled trial of prophylactic antibiotics before insertion of intrauterine devices.
        Lancet. 1998; 351: 1005-1008
        • American College of Obstetrics and Gynecology
        Antibiotics and gynecologic infections.
        Int J Gynecol Obstet. 1997; 237: 333-340
        • Charles D.
        • Edwards W.
        Infectious complications of cervical cerclage.
        Am J Obstet Gynecol. 1981; 141: 1065-1071