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Mini-symposium: The pathogenesis of pre-eclampsia| Volume 9, ISSUE 4, P196-202, December 1999

The kidney and the pathogenesis of pre-eclampsia

DOI:https://doi.org/10.1054/cuog.1999.0039
The kidney and the pathogenesis of pre-eclampsia
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      Abstract

      This review emphasizes that whatever the pathogenesis of pre-eclampsia, the ultimate target is the maternal vascular endothelium which is in abundance within the kidneys. Glomerular capillary endotheliosis is accompanied by decreased renal haemodynamics, disordered renal vascular sensitivity, hypofiltration and loss of permselectivity with non-selective proteinura. Altered tubular function contributes to sodium retention and hypercuricaemia. Occasionally, functional impairment is very severe with both tubular and cortical necrosis. The renal changes of pre-eclampsia are usually fully reversible.
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      Article info

      Identification

      DOI: https://doi.org/10.1054/cuog.1999.0039

      Copyright

      © 1999 Published by Elsevier Inc. All rights reserved.

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