Discussion| Volume 9, ISSUE 3, P130-136, September 1999

Cytotoxic chemotherapy in the treatment of carcinoma of the uterine cervix

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      There is a long history of interest in the use of chemotherapy in the treatment of cancer of the uterine cervix. Response rates in patients with chemotherapy-naive disease are in excess of 50% and this has encouraged investigators to use chemotherapy as neoadjuvant treatment, as a post-surgical adjuvant, concurrently with radiation, via regional infusion and in the treatment of recurrent and metastatic disease. Recent publications have shown a benefit for the use of concurrent chemoradiation in previously untreated patients, particularly in women with bulky stage I and 11 disease. Despite this, many questions regarding the use of chemotherapy in cervix cancer remain unanswered and these include optimal drug combinations, scheduling and timing.
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