Review| Volume 29, ISSUE 10, P281-285, October 2019

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Premenstrual syndrome


      Premenstrual syndrome (PMS) is a condition characterized by a combination of psychological and physical symptoms that begin during the luteal phase of the menstrual cycle, cease by the end of menstruation, with a symptom-free period till ovulation. A thorough history, along with other assessment tools, both in primary care and secondary care, is key in identifying and classifying the severity of the symptoms, which can range from mild to very severe. Symptoms can really affect a woman's quality of life and with up to 8% of women debilitated by severe PMS, it is vital that they are appropriately identified using investigations available and managed accordingly. Treatment can range from complementary therapies to hormonal and non-hormonal medication, to even surgery, and is introduced in a step-wise manner, often involving a multidisciplinary team. This review outlines the theories of the pathophysiology surrounding the condition, the classification of the disease, key investigations and management options advised in guidelines and research.


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      Further reading

        • American Psychiatric Association
        Diagnostic and statistical manual of mental disorders (DSM-V).
        5th edn. APA, Washington DC2013
        • Borenstein J.E.
        • Dean B.B.
        • Yonkers K.A.
        Endicott. Using the daily record of severity of problems as a screening instrument for premenstrual syndrome.
        Obstet Gynecol. 2007; 109: 1068-1075
        • Kadian S.
        • O'Brien S.
        Classification of premenstrual disorders as proposed by the international society for premenstrual disorders.
        Menopause Int. 2012; 18: 43-47
        • Marjoribanks J.
        • Brown J.
        • O'Brien P.M.
        • Wyatt K.
        Selective serotonin reuptake inhibitors for premenstual syndrome.
        Cochrane Database Syst Rev. 2013; 6 (CD001396)
        • Nevatte T.
        • O'Brien P.M.
        • B€ackstr€om T.
        • et al.
        Consensus group of the international society for premenstrual disorders. ISPMD consensus on the management of premenstrual disorders.
        Arch Womens Ment Health. 2013; 16: 279-291
        • O'Brien P.M.S.
        • Bäckström T.
        • Brown C.
        • et al.
        Towards a consensus on diagnostic criteria, measurement and trial design of the premenstrual disorders: the ISPMD Montreal consensus.
        Arch Womens Ment Health. 2011; 14: 13-21
        • Royal College of Obstetricians and Gynaecologists
        Management of premenstrual syndrome (Green-top guideline No. 48).
        RCOG, London2016
        • Spinelli M.G.
        Depression and hormone therapy.
        Clin Obstet Gynecol. 2004; 47: 428-436
        • Yonkers
        • O'Brien P.M.
        • Eriksson E.
        Premenstrual syndrome.
        Lancet. 2008; 371: 1200-1210