Case-Based Learning| Volume 32, ISSUE 1, P14-19, January 2022

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Neurological disease in pregnancy

Published:December 02, 2021DOI:


      Neurological disease encompasses a broad spectrum of conditions which may be affected by pregnancy, present de novo in pregnancy, or are caused by the pregnancy itself. Neurological diseases remain the second most common cause of indirect maternal deaths in the UK. It is imperative that a thorough history and examination are performed when assessing pregnant women presenting with neurological conditions, and that early specialist advice is sought. Multidisciplinary team working is also integral when caring for these women. These points are highlighted with the aid of case studies, with a particular focus on epilepsy, headaches, stroke, multiple sclerosis and myasthenia gravis in pregnancy.


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      Further reading

        • Cauldwell M.
        • Rudd A.
        • Nelson-Piercy C.
        Management of stroke and pregnancy.
        Eur Stroke J. 2018; 3: 227-236
        • Dobson R.
        • Dassan P.
        • Roberts M.
        • et al.
        UK consensus on pregnancy in multiple sclerosis: ‘Association of British Neurologists’ guidelines.
        Pract Neurol. 2019; 19: 106-114
        • Medicines and Healthcare products Regulatory Agency
        Epilepsy medicines and pregnancy.
        MHRA, 2021
        • Norwood F.
        • Dhanjal M.
        • Hill M.
        • et al.
        Myasthenia in pregnancy: best practice guidelines from a U.K. multispecialty working group.
        J Neurol Neurosurg Psychiatry. 2014; 85: 538-543
        • Royal College of Physicians
        Acute Care Toolkit 15: managing acute medical problems in pregnancy.
        RCP, 2019