Methenamine as prophylaxis for recurrent urinary tract infections: an overview of the ALTAR trial

Published:October 18, 2022DOI:


      Current recommended treatment for recurrent uncomplicated urinary tract infections in women includes low-dose daily antibiotics. The UK Antimicrobial Resistance Strategy document underlines the importance of non-antibiotic preventive treatments for common infections such as UTIs. The ALTAR trial investigated the clinical effectiveness of one such non-antibiotic treatment, the urinary antiseptic Methenamine Hippurate in the context of a randomised, open-label, pragmatic, two-arm non-inferiority trial with the comparator of daily low-dose antibiotics. Non-inferiority was confirmed in this study and the authors recommend that it should now be considered as a first-line preventive treatment for recurrent uncomplicated urinary tract infections in women.


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      Further reading

      1. European Association of Urology. EAU Guidelines - Urological Infections. Edn. presented at the EAU Annual Congress Amsterdam the Netherlands 2020. ISBN 978-94-92671-07-3.

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        Cochrane Database Syst Rev. 2012; 10 (Published 2012 Oct 17): CD003265
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        • UK Government, Tackling antimicrobial resistance 2019–2024: The UK’s five-year national action plan