Principles of controlled ovarian stimulation for assisted reproduction

Published:February 16, 2023DOI:


      This article provides an overview of the ovarian stimulation protocols used in assisted reproductive techniques (ART). Individual approach to ovarian stimulation involves routine measurements of ovarian reserve (OR) prior to in vitro fertilization (IVF) cycle. It helps to identify patients at risk of poor and hyper-response to gonadotrophins. The latter is associated with potentially serious complication of ovarian stimulation, ovarian hyperstimulation syndrome (OHSS). Over the years, different methods have been implemented to reduce the risk of developing ovarian hyperstimulation syndrome in predicted hyper-responders. Modified protocols of controlled ovarian stimulation (COS) allow safe and timely completion of fertility preservation treatment in patient newly diagnosed with cancer prior to start of gonadotoxic therapy.



      COS (controlled ovarian stimulation), IVF (in vitro fertilization), OHSS (ovarian hyperstimulation syndrome), ORT (ovarian reserve tests)
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      Further reading

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