Abstract
Women with inherited bleeding disorders in pregnancy are a group of pregnant women
with varied and often complex healthcare needs. The antenatal, intrapartum and postnatal
care of these women and their babies may require specialist planning and support.
This article outlines the key principles of care and provides a summary of the existing
Royal College of Obstetricians and Gynaecologists’ guidelines on the management of
inherited bleeding disorders in addition to practical advice from clinical experience
of looking after these women and their pregnancies.
Keywords
Abbreviations:
von Willebrands Disease (vWD), von Willebrands Factor (vWF), tranexamic acid (TXA), intravenous immunoglobulins (IVIG)To read this article in full you will need to make a payment
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Further reading
- Intensive menstrual bleeding successfully treated with recombinant FVIIa in Glanzmann's thrombasthenia.Clin Appl Thromb Hemost. 2011; 17: 320-322
- The obstetric experience of women with factor XI deficiency.Acta Obstet Gynecol Scand. 2009; 88: 1095-1100
- Glanzmann's thrombesthenia: the spectrum of clinical disease.Blood. 1990; 75: 1383-1395
- Kadir R.A. James P.D. Lee C.A. Inherited bleeding disorders in women. Chapter 7. John Wiley & Sons, 2019 Jan 29
- Pregnancy outcome in Factor XI deficiency: incidence of miscarriage, antenatal and postnatal haemorrhage in 33 women with Factor XI deficiency.BJOG. 2007; 114: 643-646
- Management of inherited bleeding disorders in pregnancy. Green-Top guideline No. 71.BJOG. 2017; 124: e194-e263
- Bleeding disorders, menorrhagia and iron deficiency: impacts on health-related quality of life.Haemophilia. 2013; 19: 385-391
- Plasma replacement therapy during labor is not mandatory for women with severe factor XI deficiency.Blood Coagul Fibrinolysis. 2005; 16: 37-41
- Haemostasis in normal pregnancy.Thromb Haemostasis. 1984; 52: 176-182
Article info
Publication history
Published online: March 03, 2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Elsevier Ltd. All rights reserved.
